The need for better noninvasive sample collection
The use of swabs (buccal, nasopharyngeal, wound, etc.. ) for non-invasive sample collection is well established. However the current sample collection process using swabs either allows for the collection and transport of a single swab in a specialized transport medium or the sample is collected by using two swabs at the most then transported in a mail envelope. This sample collection process not only compromises the integrity of the sample, but in many cases results in low sample output making it not ideal for downstream applications such as immune or genomics based assays.
Specialized saliva collection is another non-invasive sample collection method that is starting to be a preferred method over buccal swab and traditional mouth wash collection methods. Even though saliva collection allows for high recovery of human genomic DNA, the cost of the saliva collection devices, length of collection time, collection compliance, processing (automation) and storage remain major obstacles towards further adoption of this method to challenge blood sample collection.
The iSWAB™ devices have been designed to address the low DNA recovery and quality (ie. high content of bacterial DNA), cost and processing issues that current noninvasive sample collection approaches suffers from. The innovative design of iSWAB allows for removal of the cells captured by the swab and then released into a proprietary lysis and nucleic acid stabilizing buffer. The combination of the mechanistic release of cells and proprietary lysis buffer allows for the collection of high amount of cells in a concentrated manner from single or several swabs in a small amount of lysis buffer while yielding significantly low bacterial contamination. iSWAB™ devices are designed to facilitate self or assisted sample collection, sample concentration, transport, extraction and long term storage at room temperature, all in a single tube. In addition, the iSWAB™ is optimized for manual processing but can be easily adapted to common automated sample preparation liquid handling workstations.