Non-invasive sample collection device for collection and stabilization of protein and DNA in the same oral sample
Oral sample collection has gained widespread acceptance due to its non-invasive nature and because continuous visual contact of the collection process is possible. Current non-invasive collection products are designed for immediate detection using stick-based technology, but are limited to simple yes/no answers. If additional data is required, a more robust collection method coupled with high-sensitivity downstream analysis is necessary.
The iSWAB-Protein collection device allows for collection and stabilization of both proteins and DNA at the point of collection. This results in an abundance of material for multiple enzyme based immunoassays as well as genomic based analysis from the same collected sample. This adds another level of chain of custody, allowing the investigator to link the protein analysis with the DNA of the individual that the sample belongs to.
- Pharmacogenomics: Facilitate correlations of drug bioavailability and efficacy on cellular functions at the proteomics and genomics level.
- Forensics and Law Enforcement: Additional chain of custody layer; link protein analysis results with DNA from the same sample.
The unique and patented design of Mawi DNA Technologies’ iSWAB devices enables mechanistic release of cells into a proprietary lysis and stabilization buffer, resulting in the recovery of nearly all cells from single or several swabs while significantly minimizing bacterial contamination. iSWAB™ devices are designed to facilitate self sample collection, sample concentration, transport, extraction, and long term storage at room temperature, all in a single tube. The tubes are suitable for either manual or automated sample preparation on standard liquid handling robotics workstations.